For research use only. Not for therapeutic Use.
T-5224 (Cat.No:I003939) is a small molecule inhibitor that selectively targets c-Fos/activator protein-1 (AP-1) transcriptional activity. It effectively blocks the AP-1-mediated gene expression involved in inflammation and fibrosis. T-5224 has shown promise in preclinical studies as a potential therapeutic agent for various inflammatory diseases, including rheumatoid arthritis and liver fibrosis.
| Catalog Number | I003939 |
| CAS Number | 530141-72-1 |
| Synonyms | 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-oxo-2,3-dihydrobenzo[d]isoxazol-6-yl)methoxy)phenyl)propanoic acid |
| Molecular Formula | C29H27NO8 |
| Purity | ≥95% |
| Target | Transcription Factors |
| Solubility | DMSO: ≥ 31 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 3-[5-(4-cyclopentyloxy-2-hydroxybenzoyl)-2-[(3-oxo-1,2-benzoxazol-6-yl)methoxy]phenyl]propanoic acid |
| InChI | InChI=1S/C29H27NO8/c31-24-15-21(37-20-3-1-2-4-20)8-10-22(24)28(34)19-6-11-25(18(14-19)7-12-27(32)33)36-16-17-5-9-23-26(13-17)38-30-29(23)35/h5-6,8-11,13-15,20,31H,1-4,7,12,16H2,(H,30,35)(H,32,33) |
| InChIKey | DALCQQSLNPLQFZ-UHFFFAOYSA-N |
| SMILES | C1CCC(C1)OC2=CC(=C(C=C2)C(=O)C3=CC(=C(C=C3)OCC4=CC5=C(C=C4)C(=O)NO5)CCC(=O)O)O |
| Reference | </br>1:Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model. Kamide D, Yamashita T, Araki K, Tomifuji M, Tanaka Y, Tanaka S, Shiozawa S, Shiotani A.Cancer Sci. 2016 May;107(5):666-73. doi: 10.1111/cas.12914. Epub 2016 Apr 26. PMID: 26918517 Free PMC Article</br>2:T-5224, a selective inhibitor of c-Fos/activator protein-1, improves survival by inhibiting serum high mobility group box-1 in lethal lipopolysaccharide-induced acute kidney injury model. Ishida M, Ueki M, Morishita J, Ueno M, Shiozawa S, Maekawa N.J Intensive Care. 2015 Nov 14;3:49. doi: 10.1186/s40560-015-0115-2. eCollection 2015. PMID: 26579229 Free PMC Article</br>3:T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice. Izuta S, Ueki M, Ueno M, Nishina K, Shiozawa S, Maekawa N.Biotechnol Lett. 2012 Dec;34(12):2175-82. doi: 10.1007/s10529-012-1022-4. Epub 2012 Aug 25. PMID: 22927112 </br>4:Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. Uchihashi S, Fukumoto H, Onoda M, Hayakawa H, Ikushiro S, Sakaki T.Drug Metab Dispos. 2011 May;39(5):803-13. doi: 10.1124/dmd.110.037952. Epub 2011 Feb 23. PMID: 21346002 Free Article |
