t-Boc-Aminooxy-PEG2-azide

• CAT Number: I014706
• CAS Number: 252378-68-0
• Molecular Formula: C11H22N4O5
• Molecular Weight: 290.32
• Purity: ≥95%
• Synonyms: tert-butyl N-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]carbamate
• InChI: InChI=1S/C11H22N4O5/c1-11(2,3)20-10(16)14-19-9-8-18-7-6-17-5-4-13-15-12/h4-9H2,1-3H3,(H,14,16)
• InChIKey: LBQVKQFGGWKBAN-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NOCCOCCOCCN=[N+]=[N-]

t-Boc-Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. t-Boc-Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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