t-Boc-aminooxy-PEG4-propargyl

For research use only. Not for therapeutic Use.

  • CAT Number: I014720
  • CAS Number: 1895922-77-6
  • Molecular Formula: C16H29NO7
  • Molecular Weight: 347.41
  • Purity: ≥95%
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t-Boc-aminooxy-PEG4-propargyl(Cat No.:I014720)is a bifunctional compound used in chemical biology and drug development. It consists of three components: a t-Boc (tert-butoxycarbonyl) protective group for the aminooxy group, a polyethylene glycol (PEG) linker with four ethylene glycol units for solubility and flexibility, and a propargyl group that can undergo click chemistry for conjugation with other molecules. This compound is often utilized in bioorthogonal labeling, targeting drug delivery systems, or protein-protein interaction studies, providing a versatile tool for precise molecular assembly and investigation in biomedical research and therapeutic applications.


Catalog Number I014720
CAS Number 1895922-77-6
Synonyms

t-Boc-aminooxy-PEG4-propargyl;tert-butyl ((3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy)carbamate

Molecular Formula C16H29NO7
Purity ≥95%
Target PROTAC Linkers
Solubility Soluble in DMSO
IUPAC Name tert-butyl N-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]carbamate
InChI InChI=1S/C16H29NO7/c1-5-6-19-7-8-20-9-10-21-11-12-22-13-14-23-17-15(18)24-16(2,3)4/h1H,6-14H2,2-4H3,(H,17,18)
InChIKey LVCVPFTXEQBJOW-UHFFFAOYSA-N
SMILES CC(C)(C)OC(=O)NOCCOCCOCCOCCOCC#C
Reference

</br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550. </br>2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417.</br>3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016.</br>4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129. </br> </br>

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