For research use only. Not for therapeutic Use.
Boc-NH-PEG1-CH2CH2COOH (Cat No.: I014727) is a degradable (cleavable) ADC linker containing 1 unit of PEG, and also a PROTAC linker, belonging to PEG and Alkyl/ether, which can be used to synthesize antibody conjugates drug combination (ADC) and PROTAC.
| Catalog Number | I014727 |
| CAS Number | 1260092-44-1 |
| Synonyms | t-Boc-N-amido-PEG1-acid;3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoic acid |
| Molecular Formula | C10H19NO5 |
| Purity | ≥95% |
| Target | PROTAC |
| Solubility | Soluble in DMSO |
| Storage | 2-8°C |
| IUPAC Name | 3-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]propanoic acid |
| InChI | InChI=1S/C10H19NO5/c1-10(2,3)16-9(14)11-5-7-15-6-4-8(12)13/h4-7H2,1-3H3,(H,11,14)(H,12,13) |
| InChIKey | YGNSGMAPLOVGIU-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCOCCC(=O)O |
| Reference | </br>1: Zhang P, Huang Y, Liu H, Marquez RT, Lu J, Zhao W, Zhang X, Gao X, Li J, Venkataramanan R, Xu L, Li S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014 Aug;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. Epub 2014 May 22. PubMed PMID: 24856103; PubMed Central PMCID: PMC4102141.</br>2: Salmaso S, Bersani S, Scomparin A, Mastrotto F, Scherpfer R, Tonon G, Caliceti P. Tailored PEG for rh-G-CSF analogue site-specific conjugation. Bioconjug Chem. 2009 Jun;20(6):1179-85. doi: 10.1021/bc9000432. PubMed PMID: 19469471.</br></br> |
