For research use only. Not for therapeutic Use.
Boc-NH-PEG4-CH2CH2COOH（Cat No.:I014730） is a polyethylene glycol (PEG)-based linker utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It consists of a Boc-protected amine group, a PEG chain with four ethylene glycol units, and a carboxylic acid functionality. This linker enables the conjugation of a target protein-binding ligand and an E3 ubiquitin ligase-recruiting ligand, facilitating the targeted degradation of disease-causing proteins.
| Catalog Number | I014730 |
| CAS Number | 756525-91-4 |
| Synonyms | t-Boc-N-amido-PEG4-acid;2,2-dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid |
| Molecular Formula | C16H31NO8 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 2-8°C |
| IUPAC Name | 3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| InChI | InChI=1S/C16H31NO8/c1-16(2,3)25-15(20)17-5-7-22-9-11-24-13-12-23-10-8-21-6-4-14(18)19/h4-13H2,1-3H3,(H,17,20)(H,18,19) |
| InChIKey | YEIYIPDFZMLJQH-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)O |
| Reference | </br>1: Zhang P, Huang Y, Liu H, Marquez RT, Lu J, Zhao W, Zhang X, Gao X, Li J, Venkataramanan R, Xu L, Li S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014 Aug;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. Epub 2014 May 22. PubMed PMID: 24856103; PubMed Central PMCID: PMC4102141.</br>2: Salmaso S, Bersani S, Scomparin A, Mastrotto F, Scherpfer R, Tonon G, Caliceti P. Tailored PEG for rh-G-CSF analogue site-specific conjugation. Bioconjug Chem. 2009 Jun;20(6):1179-85. doi: 10.1021/bc9000432. PubMed PMID: 19469471.</br></br> |
