For research use only. Not for therapeutic Use.
t-Boc-N-amido-PEG4-NHS ester(CAT: I037037) is a PEG derivative containing an NHS ester and a Boc-protected amino group. The Boc group can be deprotected under mildly acidic conditions to form the free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. PEG Linkers may be useful in the development of antibody-drug conjugates.
| Catalog Number | I037037 |
| CAS Number | 859230-20-9 |
| Synonyms | t-Boc-N-amido-PEG4-NHS ester |
| Molecular Formula | C20H34N2O10 |
| Purity | 98% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2,5-dioxopyrrolidin-1-yl 2,2-dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oate |
| InChI | InChI=1S/C20H34N2O10/c1-20(2,3)31-19(26)21-7-9-28-11-13-30-15-14-29-12-10-27-8-6-18(25)32-22-16(23)4-5-17(22)24/h4-15H2,1-3H3,(H,21,26) |
| InChIKey | HHPGGUMKDXTEDQ-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O |
| Reference | 1: Zhang P, Huang Y, Liu H, Marquez RT, Lu J, Zhao W, Zhang X, Gao X, Li J, Venkataramanan R, Xu L, Li S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014 Aug;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. Epub 2014 May 22. PubMed PMID: 24856103; PubMed Central PMCID: PMC4102141. |
