t-Boc-N-amido-PEG5-acetic acid

• CAT Number: I044704
• CAS Number: 890152-41-7
• Molecular Formula: C17H33NO9
• Molecular Weight: 395.45
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C17H33NO9/c1-17(2,3)27-16(21)18-4-5-22-6-7-23-8-9-24-10-11-25-12-13-26-14-15(19)20/h4-14H2,1-3H3,(H,18,21)(H,19,20)
• InChIKey: OLLNIAGWMCSEJB-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCC(=O)O

BocNH-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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