For research use only. Not for therapeutic Use.
T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1].
T01-1 (0-50 nM; 3 days) anti-proliferative activity in HCC1806 cells[1].
T01-1 (1 mg/kg; i.v.; single) shows T1/2 values of 2.78 and 1.97 h in female and male rats, respectively[1].
| Catalog Number | I042755 |
| CAS Number | 2356229-14-4 |
| Synonyms | N-[2-[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]ethyl]-N-propan-2-ylmethanesulfonamide |
| Molecular Formula | C26H29N3O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C26H29N3O6S/c1-5-26(32)20-12-22-23-18(13-28(22)24(30)19(20)14-35-25(26)31)16(17-8-6-7-9-21(17)27-23)10-11-29(15(2)3)36(4,33)34/h6-9,12,15,32H,5,10-11,13-14H2,1-4H3/t26-/m0/s1 |
| InChIKey | PGWIUEMZGPWFBB-SANMLTNESA-N |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCN(C(C)C)S(=O)(=O)C)O |
| Reference | [1]. Li Deliang, et al. Camptothecin derivative and water-soluble prodrug, pharmaceutical composition preparation method, and application. Patent WO2020156189A1. |
