For research use only. Not for therapeutic Use.
T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1). T16A(inh)-C01 blocks chloride channel mediated by ANO1 with an IC50 of 8.4 μM, without interfering with calcium signaling[1].
| Catalog Number | I012189 |
| CAS Number | 171506-87-9 |
| Synonyms | ethyl 5-hydroxy-2-(phenoxymethyl)-1-benzofuran-3-carboxylate |
| Molecular Formula | C18H16O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H16O5/c1-2-21-18(20)17-14-10-12(19)8-9-15(14)23-16(17)11-22-13-6-4-3-5-7-13/h3-10,19H,2,11H2,1H3 |
| InChIKey | WMKWHWVWSKDZQK-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C(OC2=C1C=C(C=C2)O)COC3=CC=CC=C3 |
| Reference | [1]. Namkung W, et al. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21. 286(3):2365-74. |
