T338C Src-IN-1

• CAT Number: I001356
• CAS Number: 1351926-90-3
• Molecular Formula: C17H20N6O2S
• Molecular Weight: 372.447
• Purity: ≥95%
• Target: Src
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-[3-[(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl]ethenesulfonamide
• InChI: InChI=1S/C17H20N6O2S/c1-4-26(24,25)22-13-7-5-6-12(8-13)9-14-15-16(18)19-10-20-17(15)23(21-14)11(2)3/h4-8,10-11,22H,1,9H2,2-3H3,(H2,18,19,20)
• InChIKey: AAFALAKLPXVLIO-UHFFFAOYSA-N
• SMILES: CC(C)N1C2=C(C(=N1)CC3=CC(=CC=C3)NS(=O)(=O)C=C)C(=NC=N2)N

T338C Src-IN-1(CAT: I001356) is a potent and selective inhibitor targeting the T338C mutant of Src kinase, exhibiting an IC₅₀ of 111 nM, with a 10-fold increased selectivity compared to wild-type (WT) c-Src. This compound is an essential tool in signal transduction research, enabling the exploration of Src-related pathways, particularly those altered by mutations. T338C Src-IN-1 provides valuable insights into the role of Src kinase mutations in cancer and other diseases, supporting the development of targeted therapies. Its high selectivity allows for precise studies of mutant-specific Src activity and downstream signaling effects.