T338C Src-IN-2

• CAT Number: I001357
• CAS Number: 1351927-00-8
• Molecular Formula: C17H18FN5O
• Molecular Weight: 327.363
• Purity: ≥95%
• Target: Src
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 1-[3-[(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl]-2-fluoroethanone
• InChI: InChI=1S/C17H18FN5O/c1-10(2)23-17-15(16(19)20-9-21-17)13(22-23)7-11-4-3-5-12(6-11)14(24)8-18/h3-6,9-10H,7-8H2,1-2H3,(H2,19,20,21)
• InChIKey: WEPKWIAJJGCTLW-UHFFFAOYSA-N
• SMILES: CC(C)N1C2=C(C(=N1)CC3=CC=CC(=C3)C(=O)CF)C(=NC=N2)N

T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.

Reference

[1]. Garske AL, et al. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15046-52.