For research use only. Not for therapeutic Use.
t6A is a universally conserved, essential modified nucleoside found in transfer RNAs (tRNAs) responsible for ANN codons in all three domains of life.
| Catalog Number | I036933 |
| CAS Number | 24719-82-2 |
| Synonyms | t6A; t-6-A; t 6 A; t(6)A; N6-Threonylcarbamoyladenosine; N-(6-Nebularinylcarbamoyl)threonine; |
| Molecular Formula | C15H20N6O8 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | ((9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)carbamoyl)-L-threonine |
| InChI | InChI=1S/C15H20N6O8/c1-5(23)7(14(26)27)19-15(28)20-11-8-12(17-3-16-11)21(4-18-8)13-10(25)9(24)6(2-22)29-13/h3-7,9-10,13,22-25H,2H2,1H3,(H,26,27)(H2,16,17,19,20,28)/t5-,6-,7+,9-,10-,13-/m1/s1 |
| InChIKey | UNUYMBPXEFMLNW-DWVDDHQFSA-N |
| SMILES | O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C2N=CN=C3NC(N[C@@H]([C@H](O)C)C(O)=O)=O)[C@@H]1O |
| Reference | 1: Thiaville PC, Iwata-Reuyl D, de Crécy-Lagard V. Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNA. RNA Biol. 2014;11(12):1529-39. doi: 10.4161/15476286.2014.992277. Review. PubMed PMID: 25629598; PubMed Central PMCID: PMC4615747. |
