TA-02

• CAT Number: I002313
• CAS Number: 1784751-19-4
• Molecular Formula: C₂₀H₁₃F₂N₃
• Molecular Weight: 333.33
• Purity: ≥95%
• Synonyms: 4-(2-(2-fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine
• Target: HSC
• Solubility: 10 mM in DMSO
• Storage: Store at +4°C
• IC50: 20 nM
• IUPAC Name: 4-[2-(2-fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine
• InChI: InChI=1S/C20H13F2N3/c21-15-7-5-13(6-8-15)18-19(14-9-11-23-12-10-14)25-20(24-18)16-3-1-2-4-17(16)22/h1-12H,(H,24,25)
• InChIKey: QIFJOFNVIVQRNJ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)F

TA-02（Cat No.:I002313）is a selective inhibitor of the enzyme autotaxin (ATX), which plays a key role in the production of lysophosphatidic acid (LPA), a bioactive lipid involved in cell proliferation, migration, and survival. By inhibiting autotaxin, TA-02 effectively reduces LPA levels, leading to decreased cell signaling associated with tumor progression, inflammation, and fibrosis. TA-02 is used in research to study the role of autotaxin-LPA signaling in cancer, pulmonary fibrosis, and other pathological conditions, making it a valuable tool for exploring novel therapeutic approaches targeting this pathway.

Reference

[1]. Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.

[2]. Filip LACO, et al. 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis. WO 2015119579 A1.