For research use only. Not for therapeutic Use.
Tachykinin Antagonist 1 (Cat No.:I020517) is a compound that blocks the action of tachykinins, a family of neuropeptides including substance P, neurokinin A, and neurokinin B. These peptides are involved in various physiological processes, including inflammation, pain perception, and smooth muscle contraction. By inhibiting tachykinin receptors (particularly NK1, NK2, and NK3), TA-1 may help treat conditions like chronic pain, asthma, irritable bowel syndrome, and other disorders linked to excessive tachykinin activity. Research is ongoing to explore its therapeutic potential in managing pain, inflammatory diseases, and other related conditions.
| Catalog Number | I020517 |
| CAS Number | 178310-77-5 |
| Molecular Formula | C₂₄H₃₅Cl₂N₅O₃S |
| Purity | ≥95% |
| IUPAC Name | 4-[1-[2-[1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]piperazine-1-sulfonamide |
| InChI | InChI=1S/C24H35Cl2N5O3S/c25-21-4-3-19(13-22(21)26)24(6-5-23(32)30(17-24)14-18-1-2-18)7-8-28-15-20(16-28)29-9-11-31(12-10-29)35(27,33)34/h3-4,13,18,20H,1-2,5-12,14-17H2,(H2,27,33,34) |
| InChIKey | OQXJUJDDCWHRLA-UHFFFAOYSA-N |
| SMILES | C1CC1CN2CC(CCC2=O)(CCN3CC(C3)N4CCN(CC4)S(=O)(=O)N)C5=CC(=C(C=C5)Cl)Cl |
| Reference | [1]. Mackenzie, Alexander Roderick, et al. (Azetidin-1-ylalkyl) lactams as tachykinin antagonists. US5968923. |
