Tachysterol-3

• CAT Number: R056479
• CAS Number: 17592-07-3
• Molecular Formula: C27H44O
• Molecular Weight: 384.648
• Purity: ≥95%
• Synonyms: Tachysterol-3;(1S)-3-[(1E)-2-[(1R,3aR,7aR)-1-[(1R)-1,5-Dimethylhexyl]-2,3,3a,6,7,7a-hexahydro-7a-methyl-1H-inden-4-yl]ethenyl]-4-methyl-3-cyclohexen-1-ol; (3β,6E)-9,10-Secocholesta-5(10),6,8-trien-3-ol
• Target: Metabolic Enzyme/Protease
• Storage: Store at -20°C
• IUPAC Name: (1S)-3-[(E)-2-[(1R,3aR,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-4-methylcyclohex-3-en-1-ol
• InChI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12+/t21-,24+,25-,26+,27-/m1/s1
• InChIKey: YUGCAAVRZWBXEQ-FMCTZRJNSA-N
• SMILES: CC1=C(CC(CC1)O)C=CC2=CCCC3(C2CCC3C(C)CCCC(C)C)C

Tachysterol-3 is a sterol derivative formed during the UV-induced photoconversion of 7-dehydrocholesterol, alongside vitamin D3 and lumisterol. It is an intermediate in the complex biosynthesis of vitamin D3 in the skin, specifically arising from the isomerization of previtamin D3. Tachysterol-3 itself has minimal biological activity but plays a crucial role in the regulatory mechanisms of vitamin D metabolism. Its formation helps maintain a balance of vitamin D metabolites, ensuring that excess UV exposure does not lead to overproduction of active vitamin D, thus protecting against hypercalcemia.

Overview of Clinical Research

The phase 4 study for the adminidtration of preoperative vitamin D as prevention in transitory hypocalcemia in postoperatory of total thyroidectomy is on going in EU.