For research use only. Not for therapeutic Use.
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM[1].
TAK-071 increase hippocampal inositol monophosphate production through M1R activation and improved DB00747
-induced cognitive deficits in rats at 0.3 mg/kg[1].
TAK-071 also induce diarrhea at 10 mg/kg in rats[1].
Combining sub-effective doses of TAK-071 (3 mg/kg) with an acetylcholinesterase inhibitor significantly ameliorates DB00747-induced cognitive deficits in rats[1].
| Catalog Number | I019569 |
| CAS Number | 1820812-16-5 |
| Synonyms | 4-fluoro-2-[(3S,4S)-4-hydroxyoxan-3-yl]-5-methyl-6-[(4-pyrazol-1-ylphenyl)methyl]-3H-isoindol-1-one |
| Molecular Formula | C24H24FN3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H24FN3O3/c1-15-17(11-16-3-5-18(6-4-16)28-9-2-8-26-28)12-19-20(23(15)25)13-27(24(19)30)21-14-31-10-7-22(21)29/h2-6,8-9,12,21-22,29H,7,10-11,13-14H2,1H3/t21-,22-/m0/s1 |
| InChIKey | WFSARWQASFQZMG-VXKWHMMOSA-N |
| SMILES | CC1=C(C2=C(C=C1CC3=CC=C(C=C3)N4C=CC=N4)C(=O)N(C2)C5COCCC5O)F |
| Reference | [1]. Sako Y, et al. TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects. Neuropsychopharmacology. 2018 Aug 1. doi: 10.1038/s41386-018-0168-8. |
