For research use only. Not for therapeutic Use.
TAK-220（Cat No.:I003210）is a potent and selective antagonist of the chemokine receptor CCR5, which is involved in immune cell trafficking and plays a crucial role in HIV infection and inflammatory processes. By blocking CCR5, TAK-220 prevents the entry of HIV into host cells, making it a promising candidate in the development of antiretroviral therapies. Its ability to inhibit CCR5 signaling also has potential applications in treating inflammatory diseases and certain cancers where CCR5 is implicated in cell migration and tumor progression. TAK-220 remains of interest in both HIV and immunological research.
| Catalog Number | I003210 |
| CAS Number | 333994-00-6 |
| Molecular Formula | C31H41ClN4O3 |
| Purity | ≥95% |
| Target | Immunology/Inflammation |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 1-acetyl-N-[3-[4-[(4-carbamoylphenyl)methyl]piperidin-1-yl]propyl]-N-(3-chloro-4-methylphenyl)piperidine-4-carboxamide |
| InChI | InChI=1S/C31H41ClN4O3/c1-22-4-9-28(21-29(22)32)36(31(39)27-12-18-35(19-13-27)23(2)37)15-3-14-34-16-10-25(11-17-34)20-24-5-7-26(8-6-24)30(33)38/h4-9,21,25,27H,3,10-20H2,1-2H3,(H2,33,38) |
| InChIKey | ASSJTMUEFHUKMJ-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)N(CCCN2CCC(CC2)CC3=CC=C(C=C3)C(=O)N)C(=O)C4CCN(CC4)C(=O)C)Cl |
| Reference | </br>1:Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity. Imamura S, Ichikawa T, Nishikawa Y, Kanzaki N, Takashima K, Niwa S, Iizawa Y, Baba M, Sugihara Y.J Med Chem. 2006 May 4;49(9):2784-93. PMID: 16640339 </br>2:Analysis of binding sites for the new small-molecule CCR5 antagonist TAK-220 on human CCR5. Nishikawa M, Takashima K, Nishi T, Furuta RA, Kanzaki N, Yamamoto Y, Fujisawa J.Antimicrob Agents Chemother. 2005 Nov;49(11):4708-15. PMID: 16251315 Free PMC Article</br>3:TAK-220, a novel small-molecule CCR5 antagonist, has favorable anti-human immunodeficiency virus interactions with other antiretrovirals in vitro. Tremblay CL, Giguel F, Guan Y, Chou TC, Takashima K, Hirsch MS.Antimicrob Agents Chemother. 2005 Aug;49(8):3483-5. PMID: 16048964 Free PMC Article</br>4:Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist. Takashima K, Miyake H, Kanzaki N, Tagawa Y, Wang X, Sugihara Y, Iizawa Y, Baba M.Antimicrob Agents Chemother. 2005 Aug;49(8):3474-82. PMID: 16048963 Free PMC Article |
