TAK-242

• CAT Number: I002819
• CAS Number: 243984-11-4
• Molecular Formula: C15H17NO4ClFS
• Molecular Weight: 361.80
• Purity: ≥95%
• Synonyms: Resatorvid;TAK-242;TAK242;TAK 242
• Target: Apoptosis
• Solubility: DMSO 10 mg/ml; DMF 10 mg/ml
• Storage: Store at -20°C
• IC50: 1.1-11 nM
• IUPAC Name: ethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohexene-1-carboxylate
• InChI: 1S/C15H17ClFNO4S/c1-2-22-15(19)11-5-3-4-6-14(11)23(20,21)18-13-8-7-10(17)9-12(13)16/h5,7-9,14,18H,2-4,6H2,1H3/t14-/m1/s1
• InChIKey: LEEIJTHMHDMWLJ-CQSZACIVSA-N
• SMILES: FC1=CC(Cl)=C(NS([C@@H]2CCCC=C2C(OCC)=O)(=O)=O)C=C1

TAK-242(CAT: I002819), also known as resatorvid, is a small-molecule inhibitor of Toll-like receptor 4 (TLR4) signaling, which plays a crucial role in the innate immune response. By selectively binding to TLR4 and disrupting its interaction with downstream signaling molecules, TAK-242 can inhibit the production of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β, that contribute to the pathogenesis of various inflammatory diseases. TAK-242 has been investigated as a potential therapeutic agent for sepsis, arthritis, atherosclerosis, and other inflammatory disorders, and has shown promising results in preclinical and clinical studies.