TAK-438

• CAT Number: I001040
• CAS Number: 1260141-27-2
• Molecular Formula: C21H20FN3O6S
• Molecular Weight: 461.46
• Purity: ≥95%
• Synonyms: (E)-but-2-enedioic acid;1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine
• Target: ATPase
• Solubility: in DMSO > 10 mM
• Storage: 3 years -20℃ powder
• IC50: 19 nM [1]
• InChI: InChI=1S/C17H16FN3O2S.C4H4O4/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14;5-3(6)1-2-4(7)8/h2-9,11-12,19H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChIKey: ROGSHYHKHPCCJW-WLHGVMLRSA-N
• SMILES: CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=CC(=O)O)C(=O)O

TAK-438 (Cat.No:I001040) is a potassium-competitive acid blocker (P-CAB) and proton pump inhibitor (PPI) used to treat gastrointestinal conditions, such as acid reflux and peptic ulcers. It works by suppressing gastric acid production more effectively than traditional PPIs, providing rapid and long-lasting relief. TAK-438 is considered a promising option in managing acid-related disorders.

Reference

[1]. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.
[2]. Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238.
[3]. Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.