Talampanel

• CAT Number: I002075
• CAS Number: 161832-65-1
• Molecular Formula: C19H19N3O3
• Molecular Weight: 337.37
• Purity: ≥95%
• Synonyms: (R)-1-(5-(4-aminophenyl)-8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4/’,5/’:4,5]benzo[1,2-d][1,2]diazepin-7-yl)ethanone
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
• InChI: InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
• InChIKey: JACAAXNEHGBPOQ-LLVKDONJSA-N
• SMILES: C[C@H]1N(C(C)=O)N=C(C2=CC=C(N)C=C2)C3=CC(OCO4)=C4C=C3C1

Talampanel is a non-competitive antagonist of the AMPA receptors, which are involved in the transmission of excitatory signals in the brain. By inhibiting these receptors, talampanel helps reduce excessive neuronal activity, making it a potential treatment for neurological conditions such as epilepsy and neurodegenerative diseases. It has been studied for its ability to prevent seizures and manage conditions associated with abnormal glutamate signaling. Despite promising results in preclinical studies, its clinical development has been limited.