Talampanel

• CAT Number: I002075
• CAS Number: 161832-65-1
• Molecular Formula: C19H19N3O3
• Molecular Weight: 337.37
• Purity: ≥95%
• Synonyms: (R)-1-(5-(4-aminophenyl)-8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4/’,5/’:4,5]benzo[1,2-d][1,2]diazepin-7-yl)ethanone
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
• InChI: InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
• InChIKey: JACAAXNEHGBPOQ-LLVKDONJSA-N
• SMILES: C[C@H]1N(C(C)=O)N=C(C2=CC=C(N)C=C2)C3=CC(OCO4)=C4C=C3C1

Talampanel(CAT: I002075) is a non-competitive antagonist of the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor, a subtype of glutamate receptor critical for excitatory neurotransmission in the central nervous system. By inhibiting AMPA receptor activity, Talampanel reduces excitotoxicity, making it valuable in neuroscience research focused on conditions such as epilepsy, amyotrophic lateral sclerosis (ALS), and other neurodegenerative diseases. Its neuroprotective properties provide insights into glutamate-mediated neuronal damage and therapeutic approaches to modulate excitatory signaling. Talampanel is a crucial tool for advancing research into neurological disorders and developing potential treatments targeting glutamatergic pathways.