(+)-Talarozole

• CAT Number: I020464
• CAS Number: 201410-66-4
• Molecular Formula: C₂₁H₂₃N₅S
• Molecular Weight: 377.51
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine
• InChI: InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)
• InChIKey: SNFYYXUGUBUECJ-UHFFFAOYSA-N
• SMILES: CCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4

(+)-Talarozole（Cat No.:I020464）is a selective retinoic acid metabolism blocking agent (RAMBA) that inhibits the enzyme CYP26, responsible for degrading retinoic acid (RA). By blocking RA breakdown, talarozole increases RA levels, enhancing its effects on cell differentiation and proliferation. This makes it valuable for research and potential treatment of dermatological conditions like psoriasis and acne, where RA plays a critical role in skin cell turnover. Talarozole’s targeted action on RA pathways has led to its exploration in other areas, including oncology, where RA signaling influences tumor growth and differentiation.

Reference

[1]. Marc Gaston Venet, et al. N-[4-(heteroarylmethyl)phenyl]-heteroarylamines. WO 1997049704 A1.