Talipexole

• CAT Number: I000130
• CAS Number: 101626-70-4
• Molecular Formula: C10H15N3S
• Molecular Weight: 209.31
• Purity: ≥95%
• Synonyms: B-HT920
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IUPAC Name: 6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine
• InChI: InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12)
• InChIKey: DHSSDEDRBUKTQY-UHFFFAOYSA-N
• SMILES: C=CCN1CCC2=C(CC1)SC(=N2)N

Talipexole（Cat No.:I000130）is a selective dopamine D3 receptor agonist that has been studied for its potential therapeutic effects in treating Parkinson’s disease and other neurological conditions. It works by stimulating D3 receptors, which are involved in the regulation of movement, motivation, and reward. Talipexole may help to improve motor function and reduce symptoms such as rigidity and tremors in Parkinson’s disease patients. Additionally, it has been explored for its potential in treating depression and drug addiction due to its effects on dopamine pathways. Clinical studies are ongoing to evaluate its efficacy and safety in these conditions.

Reference

[1]. Van der Laan, J.W., Dopaminergic and alpha 1-adrenergic properties of B-HT920 revealed in morphine-dependent rats. Pharmacol Biochem Behav, 1987. 26(2): p. 265-9. 


[2]. Kitamura, Y., J. Kakimura, and T. Taniguchi, Protective effect of talipexole on MPTP-treated planarian, a unique parkinsonian worm model. Jpn J Pharmacol, 1998. 78(1): p. 23-9.