Talmapimod HCl

• CAT Number: I012013
• CAS Number: 309915-12-6
• Molecular Formula: C27H31Cl2FN4O3
• Molecular Weight: 549.47
• Purity: ≥95%
• Synonyms: SCIO469, SCIO-469, SCI O469, Talmapimod, Talmapimod HCl;2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide hydrochloride
• Target: p38 MAPK
• Solubility: Soluble in DMSO, not in water
• Storage: Store at 0-8 °C
• IUPAC Name: 2-[6-chloro-5-[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine-1-carbonyl]-1-methylindol-3-yl]-N,N-dimethyl-2-oxoacetamide;hydrochloride
• InChI: InChI=1S/C27H30ClFN4O3.ClH/c1-16-13-33(17(2)12-32(16)14-18-6-8-19(29)9-7-18)26(35)21-10-20-22(25(34)27(36)30(3)4)15-31(5)24(20)11-23(21)28;/h6-11,15-17H,12-14H2,1-5H3;1H/t16-,17+;/m0./s1
• InChIKey: FOJUFGQLUOOBQP-MCJVGQIASA-N
• SMILES: CC1CN(C(CN1C(=O)C2=C(C=C3C(=C2)C(=CN3C)C(=O)C(=O)N(C)C)Cl)C)CC4=CC=C(C=C4)F.Cl

Talmapimod HCl(CAT: I012013) is a high-purity inhibitor targeting p38 mitogen-activated protein kinase (MAPK), a key regulator in inflammatory and stress-response pathways. This compound effectively modulates the production of pro-inflammatory cytokines such as TNF-α and IL-1β, making it a valuable tool in research on inflammation-driven conditions, autoimmune disorders, and cancer. Its high selectivity and reliability ensure precise experimental outcomes in cellular signaling studies. Talmapimod HCl is ideal for investigating the molecular mechanisms underlying inflammation and for exploring potential therapeutic approaches in drug discovery. With excellent stability and consistency, it supports a broad range of biomedical research applications.