For research use only. Not for therapeutic Use.
Talotrexin is an antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance.
| CAS Number | 113857-87-7 |
| Molecular Formula | C27H27N9O6 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | Desiccate at -20C |
| Related CAS | 648420-92-2(ammonium salt) |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
