For research use only. Not for therapeutic Use.
Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes[1][2][3][4]. Talsaclidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Catalog Number | R003847 |
| CAS Number | 147025-53-4 |
| Synonyms | (3R)-3-prop-2-ynoxy-1-azabicyclo[2.2.2]octane |
| Molecular Formula | C10H15NO |
| Purity | ≥95% |
| InChI | InChI=1S/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1 |
| InChIKey | XVFJONKUSLSKSW-JTQLQIEISA-N |
| SMILES | C#CCOC1CN2CCC1CC2 |
| Reference | [1]. Ensinger HA, et al. WAL 2014–a muscarinic agonist with preferential neuron-stimulating properties. Life Sci. 1993;52(5-6):473-80. [2]. Wienrich M, et al. Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man. Life Sci. 2001 Apr 27;68(22-23):2593-600. [3]. Walland A, et al. In vivo consequences of M1-receptor activation by talsaclidine. Life Sci. 1997;60(13-14):977-84. [4]. Walland A, et al. Compensation of muscarinic bronchial effects of talsaclidine by concomitant sympathetic activation in guinea pigs. Eur J Pharmacol. 1997 Jul 9;330(2-3):213-9. |
