TAM557 TFA

• CAT Number: I040105
• Molecular Formula: C52H85F3N8O13S
• Molecular Weight: 1119.34
• Purity: ≥95%
• Synonyms: 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl N-[[(2S,4R)-5-(4-hydroxyphenyl)-2-methyl-4-[[2-[(1R,3R)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]-propylamino]-1-propoxypentyl]-1,3-thiazole-4-carbonyl]amino]pentanoyl]amino]carbamate;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C50H84N8O11S.C2HF3O2/c1-9-20-58(49(63)44(35(6)11-3)54-47(62)41-14-12-13-21-57(41)8)42(34(4)5)32-43(68-22-10-2)48-53-40(33-70-48)46(61)52-38(31-37-15-17-39(59)18-16-37)30-36(7)45(60)55-56-50(64)69-29-28-67-27-26-66-25-24-65-23-19-51;3-2(4,5)1(6)7/h15-18,33-36,38,41-44,59H,9-14,19-32,51H2,1-8H3,(H,52,61)(H,54,62)(H,55,60)(H,56,64);(H,6,7)/t35-,36-,38+,41+,42+,43+,44-;/m0./s1
• InChIKey: BSLBFEDMNJKDQK-NVOAYPLDSA-N
• SMILES: CCCN(C(CC(C1=NC(=CS1)C(=O)NC(CC2=CC=C(C=C2)O)CC(C)C(=O)NNC(=O)OCCOCCOCCOCCN)OCCC)C(C)C)C(=O)C(C(C)CC)NC(=O)C3CCCCN3C.C(=O)(C(F)(F)F)O

TAM557 TFA (Cat No.: I040105) is a small-molecule compound used primarily in cancer research, particularly for its potential to inhibit key signaling pathways involved in tumor cell proliferation and survival. It is a potent inhibitor of certain kinases or enzymes that regulate cell growth, apoptosis, and metastasis. The TFA (trifluoroacetate) salt form enhances the solubility and stability of the compound for research purposes. Preclinical studies suggest that TAM557 TFA may be effective in targeting specific cancer types, offering a potential strategy for targeted therapies.

Reference

[1]. Wolfgang Richter, et al., Cytotoxic tubulysin compounds and conjugates thereof. Patent WO2015113760A1.