Tamoxifen-d5

• CAT Number: R003188
• CAS Number: 157698-32-3
• Molecular Formula: C26H24D5NO
• Molecular Weight: 376.6
• Purity: ≥95%
• Synonyms: (Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-butene-3,3,4,4,4-d5; ?(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine-d5; ICI 47699-d5; Mammaton-d5; Novaldex-d5; Tamoxifen-d5; Z-Tamoxifen-d5; trans-Tamoxifen-d5
• Target: Metabolic Enzyme/Protease
• Storage: 4°C
• IUPAC Name: N,N-dimethyl-2-[4-[(Z)-3,3,4,4,4-pentadeuterio-1,2-diphenylbut-1-enyl]phenoxy]ethanamine
• InChI: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-/i1D3,4D2
• InChIKey: NKANXQFJJICGDU-FUYVPVGLSA-N
• SMILES: [2H]C([2H])([2H])C([2H])([2H])/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3

Tamoxifen-d5 is a deuterated form of tamoxifen, where five hydrogen atoms have been replaced with deuterium. This isotopically labeled compound is primarily used in pharmaceutical research to study the metabolism, pharmacokinetics, and pharmacodynamics of tamoxifen, a widely used selective estrogen receptor modulator (SERM) for the treatment and prevention of breast cancer. The deuterium labeling allows for precise tracking in analytical methods such as mass spectrometry, providing enhanced stability and accuracy in monitoring the drug’s distribution and metabolic pathways within the body. Tamoxifen-d5 is an invaluable tool for researchers aiming to optimize breast cancer therapies, assess drug interactions, and better understand the mechanisms of action and resistance associated with tamoxifen.