For research use only. Not for therapeutic Use.
Tandospirone citrate (Cat.No:I000471) is a medication used primarily in the treatment of anxiety disorders and depression. It acts as a selective serotonin 5-HT1A receptor partial agonist, exerting anxiolytic and antidepressant effects. Tandospirone citrate is well-tolerated and offers an alternative treatment option for individuals with anxiety and mood disorders.
| Catalog Number | I000471 |
| CAS Number | 112457-95-1 |
| Molecular Formula | C27H37N5O9 |
| Purity | ≥95% |
| Target | 5-HT1A |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20℃ powder |
| IC50 | 27±5 nM(Ki) [1] |
| IUPAC Name | 2-hydroxypropane-1,2,3-tricarboxylic acid;(1S,2R,6S,7R)-4-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-4-azatricyclo[5.2.1.02,6]decane-3,5-dione |
| InChI | InChI=1S/C21H29N5O2.C6H8O7/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3,6-7,15-18H,1-2,4-5,8-14H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t15-,16+,17+,18-; |
| InChIKey | DMLGUJHNIWGCKM-DPFKZJTMSA-N |
| SMILES | C1CC2CC1C3C2C(=O)N(C3=O)CCCCN4CCN(CC4)C5=NC=CC=N5.C(C(=O)O)C(CC(=O)O)(C(=O)O)O |
| Reference | <p style=/line-height:25px/> <br>[2]. Shimizu H, et al. Characterization of the putative anxiolytic SM-3997 recognition sites in rat brain. Life Sci. 1988;42(24):2419-27. <br>[3]. Uehara T, et al. Chronic treatment with tandospirone, a 5-HT1A receptor partial agonist, suppresses footshock stress-induced lactate production in the prefrontal cortex of rats. Pharmacol Biochem Behav. 2013 Nov 15;113:1-6. <br>[4]. Ohmura Y, et al. Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. J Pharmacol Sci. 2013;122(2):84-92. </p> |
