Tangeretin

• CAT Number: I003694
• CAS Number: 481-53-8
• Molecular Formula: C20H20O7
• Molecular Weight: 372.37
• Purity: ≥95%
• Synonyms: NSC 53909;NSC 618905;Ponkanetin
• Target: Stem Cell/Wnt
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one
• InChI: 1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
• InChIKey: VGGCDYAXGPXIHL-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC

Tangeretin (Cat No.: I003694) is a polymethoxyflavone found in citrus peel, particularly tangerines, known for its potential therapeutic benefits. It exhibits anti-inflammatory, antioxidant, and anticancer properties, making it a promising compound in disease research. Tangeretin has been studied for its role in inhibiting tumor growth, modulating cholesterol levels, and protecting neurons in neurodegenerative disorders. It also enhances drug bioavailability by inhibiting certain metabolic enzymes. Due to its diverse biological activities, tangeretin is explored in cancer, cardiovascular, and neurological disease research.

Reference

[1]. Zhang X, et al. Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. Oncol Rep. 2015 Jul;34(1):302-10.

[2]. Xu JJ, et al. Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. J Agric Food Chem. 2015 Nov 4;63(43):9520-7.

[3]. Hagenlocher Y, et al. Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells. Eur J Nutr. 2016 Mar 28.