For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.<br>IC50 value:<br>Target: Notch-1<br>In vitro: Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion [1].<br>In vivo: In this study, we investigated the in vivo anti-RSV activity of tangeretin in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice [2].</p>
| Catalog Number | I003694 |
| CAS Number | 481-53-8 |
| Synonyms | NSC 53909;NSC 618905;Ponkanetin |
| Molecular Formula | C20H20O7 |
| Purity | ≥95% |
| Target | Notch-1 |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| InChIKey | VGGCDYAXGPXIHL-UHFFFAOYSA-N |
| Reference | <p style=/line-height:25px/> <br>[2]. Xu JJ, et al. Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. J Agric Food Chem. 2015 Nov 4;63(43):9520-7. <br>[3]. Hagenlocher Y, et al. Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells. Eur J Nutr. 2016 Mar 28. </p> |
