For research use only. Not for therapeutic Use.
Taniborbactam Hydrochloride（Cat No.:I016684）is a novel, broad-spectrum beta-lactamase inhibitor designed to enhance the efficacy of beta-lactam antibiotics against multidrug-resistant Gram-negative bacteria. It works by inhibiting both serine- and metallo-beta-lactamases, which are enzymes that confer resistance to antibiotics by breaking down beta-lactam rings. Taniborbactam, often combined with antibiotics like cefepime, aims to treat severe infections caused by resistant pathogens, including carbapenem-resistant Enterobacteriaceae. Its advanced inhibition profile and efficacy against resistant bacteria make taniborbactam a promising candidate in the fight against antibiotic-resistant infections.
| Catalog Number | I016684 |
| CAS Number | 2244235-49-0 |
| Molecular Formula | C₁₉H₃₀BCl₂N₃O₅ |
| Purity | ≥95% |
| Target | Beta-lactamase |
| IUPAC Name | (3R)-3-[[2-[4-(2-aminoethylamino)cyclohexyl]acetyl]amino]-2-hydroxy-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid;dihydrochloride |
| InChI | InChI=1S/C19H28BN3O5.2ClH/c21-8-9-22-14-6-4-12(5-7-14)10-17(24)23-16-11-13-2-1-3-15(19(25)26)18(13)28-20(16)27;;/h1-3,12,14,16,22,27H,4-11,21H2,(H,23,24)(H,25,26);2*1H/t12?,14?,16-;;/m0../s1 |
| InChIKey | CKWIMFZHNCBHIX-PPJOBQAPSA-N |
| SMILES | B1([C@H](CC2=C(O1)C(=CC=C2)C(=O)O)NC(=O)CC3CCC(CC3)NCCN)O.Cl.Cl |
| Reference | [1]. Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62(18):8544-8556.<br>[2]. Liu B ,et al. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16. |
