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568-72-9-Tanshinone IIA Tanshinone IIA

Tanshinone IIA

For research use only. Not for therapeutic Use.

  • CAT Number: I004121
  • CAS Number: 568-72-9
  • Molecular Formula: C19H18O3
  • Molecular Weight: 294.3
  • Purity: ≥95%
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Related Small Molecules: GNE-781     1-tert-Butyl 4-ethyl 4-(pyridin-4-yl)piperidine-1,4-dicarboxylate     Ginsenoside Rh1    

Tanshinone IIA (Cat No.: I004121) is a derivative of tanshinone, which can inhibit tumor growth in vivo. Also maintains vasodilation activity in vivo. It is mainly used for the treatment of cardiovascular diseases. It has the functions of expanding blood vessels, lowering blood pressure, and antithrombotic, and significantly treating coronary heart disease, angina pectoris, and tachycardia.


Catalog Number I004121
CAS Number 568-72-9
Synonyms

1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione

Molecular Formula C19H18O3
Purity ≥95%
Target VEGFR
Solubility DMSO
Storage 2-8°C
IUPAC Name 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
InChI InChI=1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
InChIKey HYXITZLLTYIPOF-UHFFFAOYSA-N
SMILES CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
Reference

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<br>[1]. Xie J, et al. The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line. Acta Pharm Sin B. 2015 Nov;5(6):554-63.

<br>[2]. Zhang Z, et al. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. Am J Transl Res. 2016 Jul 15;8(7):3124-32.

<br>[3]. Su CC, et al. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016 Aug;36(2):1173-9.

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