TAO Kinase inhibitor 2

• CAT Number: I041077
• CAS Number: 850467-77-5
• Molecular Formula: C25H24N2O3
• Molecular Weight: 400.47
• Purity: ≥95%
• Synonyms: N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]-4-phenoxybenzamide
• InChI: InChI=1S/C25H24N2O3/c28-24(27-23-12-6-8-18-7-4-5-11-22(18)23)17-26-25(29)19-13-15-21(16-14-19)30-20-9-2-1-3-10-20/h1-5,7,9-11,13-16,23H,6,8,12,17H2,(H,26,29)(H,27,28)
• InChIKey: LYJAJWGXMOKLOA-UHFFFAOYSA-N
• SMILES: C1CC(C2=CC=CC=C2C1)NC(=O)CNC(=O)C3=CC=C(C=C3)OC4=CC=CC=C4

TAO Kinase inhibitor 2 (Example 49) is a TAO Kinase inhibitor (IC50=between 50 and 500 nM). TAO Kinase inhibitor 2 also inhibits KIAA1361 and JIK with IC50s of 50-500 nM[1].

Reference

[1]. Deborah Lynn Baly, et al. Tao kinase modulators and methods of use. Patent. WO2005040355.