TAPI-0

• CAT Number: I037001
• CAS Number: 163958-73-4
• Molecular Formula: C24H32N4O5
• Molecular Weight: 456.53
• Purity: ≥95%
• Synonyms: (2R)-N-[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N’-hydroxy-2-(2-methylpropyl)butanediamide
• IUPAC Name: (2R)-N-[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
• InChI: InChI=1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19+,20-/m0/s1
• InChIKey: CRCPLBFLOSEABN-BEVDRBHNSA-N
• SMILES: C[C@@H](C(=O)N)NC(=O)[C@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CC(C)C)CC(=O)NO

TAPI-0 (Cat No.:I037001) is a potent synthetic inhibitor of matrix metalloproteinases (MMPs), particularly targeting MMP-2 and MMP-9. These enzymes play key roles in the breakdown of extracellular matrix proteins, which is crucial in tissue remodeling, wound healing, and cancer metastasis. By inhibiting MMP activity, TAPI-0 helps reduce tissue degradation and inflammation, making it a potential therapeutic candidate for diseases involving excessive tissue remodeling, such as rheumatoid arthritis, cancer, and cardiovascular diseases. Its ability to modulate MMPs offers significant promise in managing chronic inflammatory conditions.