TAPI-1

• CAT Number: I002135
• CAS Number: 163847-77-6
• Molecular Formula: C26H37N5O5
• Molecular Weight: 499.60
• Purity: ≥95%
• Solubility: DMSO: ≥ 34 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (2R)-N-[(2S)-1-[[(2S)-1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
• InChI: InChI=1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21+,22-/m0/s1
• InChIKey: AWNBSWDIOCXWJW-WTOYTKOKSA-N
• SMILES: C[C@@H](C(=O)NCCN)NC(=O)[C@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CC(C)C)CC(=O)NO

TAPI-1（Cat No.:I002135）is a broad-spectrum metalloprotease inhibitor known for its ability to inhibit tumor necrosis factor-alpha converting enzyme (TACE/ADAM17) and matrix metalloproteinases (MMPs). By blocking these proteases, TAPI-1 prevents the cleavage and release of membrane-bound proteins such as TNF-α, thereby modulating inflammatory responses and reducing tissue degradation. It has been widely studied for its potential in treating inflammatory diseases, cancer, and cardiovascular conditions, where metalloprotease activity plays a crucial role. TAPI-1 is a valuable tool for researchers exploring protease-mediated pathways in various pathological conditions.

Reference

[1]. Zhang Y, et al. The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-α-EGFR pathway. Exp Lung Res. 2014 Jun 5.
[2]. Wheeler DL, et al. Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. Cancer Res. 2003 Oct 1;63(19):6547-55.
[3]. Zhao XQ, et al. CRP enhances soluble LOX-1 release from macrophages by activating TNF-α converting enzyme. J Lipid Res. 2011 May;52(5):923-33.