TAPI-2

• CAT Number: I002417
• CAS Number: 187034-31-7
• Molecular Formula: C₁₉H₃₇N₅O₅
• Molecular Weight: 415.28
• Purity: ≥95%
• Synonyms: TNF Protease Inhibitor 2
• Target: 20±10 μM (MMPs)
• Solubility: DMSO: ≥ 22 mg/mL
• Storage: -20°C
• IUPAC Name: N-[(2S)-1-[[(2S)-1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
• InChI: InChI=1S/C19H37N5O5/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25)/t12-,13?,15+/m0/s1
• InChIKey: LMIQCBIEAHJAMZ-RMTCENKZSA-N
• SMILES: C[C@@H](C(=O)NCCN)NC(=O)[C@H](C(C)(C)C)NC(=O)C(CC(C)C)CC(=O)NO

TAPI-2（Cat No.:I002417）is a selective inhibitor of tumor necrosis factor-alpha converting enzyme (TACE), also known as ADAM17, which is involved in shedding various cell surface proteins, including TNF-α and other cytokines. By inhibiting TACE, TAPI-2 reduces TNF-α release, making it a valuable tool in studying inflammatory processes and immune responses. Its ability to modulate metalloproteinase activity also makes TAPI-2 useful in cancer, fibrosis, and autoimmune disease research. TAPI-2’s targeted action helps elucidate TACE’s role in pathological pathways, aiding therapeutic exploration in inflammation and cancer treatment strategies.

Reference

[1]. Kruse MN, et al. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem J. 2004 Mar 1;378(Pt 2):383-9.
[2]. Wang R, et al. A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. Stem Cells Transl Med. 2016 Mar;5(3):331-8.