For research use only. Not for therapeutic Use.
Taprenepag(CAT: I004786) is a chemical compound that acts as a selective agonist of the prostaglandin EP2 receptor. Prostaglandin EP2 receptors are found in various tissues and play a role in regulating inflammation and pain. Taprenepag is primarily used in ophthalmology as a therapeutic agent for the treatment of glaucoma and ocular hypertension. It works by reducing intraocular pressure through the selective activation of EP2 receptors, which leads to increased aqueous humor outflow and decreased fluid production in the eye.
| Catalog Number | I004786 |
| CAS Number | 752187-80-7 |
| Synonyms | 2-[3-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-acetic acid |
| Molecular Formula | C24H22N4O5S |
| Purity | ≥95% |
| Target | Prostaglandin Receptor |
| Solubility | DMSO: ＞ 31 mg/mL |
| Storage | -20°C |
| IC50 | 2.8 nM (EC50) |
| InChIKey | MFFBXYNKZHTCEY-UHFFFAOYSA-N |
| Reference | </br>1:Investigation of ocular events associated with taprenepag isopropyl, a topical EP2 agonist in development for treatment of glaucoma. Yanochko GM, Affolter T, Eighmy JJ, Evans MG, Khoh-Reiter S, Lee D, Miller PE, Shiue MH, Trajkovic D, Jessen BA.J Ocul Pharmacol Ther. 2014 Jun;30(5):429-39. doi: 10.1089/jop.2013.0222. Epub 2014 Apr 10. PMID: 24720348 </br>2:Subclinical increased anterior stromal reflectivity with topical taprenepag isopropyl. Schachar RA, Raber S, Thomas KV, Benetz BA, Szczotka-Flynn LB, Zhang M, Howell SJ, Lass JH.Cornea. 2013 Mar;32(3):306-12. doi: 10.1097/ICO.0b013e3182523f40. PMID: 22549238 Free PMC Article</br>3:A phase 2, randomized, dose-response trial of taprenepag isopropyl (PF-04217329) versus latanoprost 0.005% in open-angle glaucoma and ocular hypertension. Schachar RA, Raber S, Courtney R, Zhang M.Curr Eye Res. 2011 Sep;36(9):809-17. doi: 10.3109/02713683.2011.593725. PMID: 21851167 |
