Tarloxotinib bromide

• CAT Number: I009707
• CAS Number: 1636180-98-7
• Molecular Formula: C24H24Br2ClN9O3
• Molecular Weight: 681.77
• Purity: ≥95%
• Synonyms: PR-610; PR 610; PR610; TH-4000; TH 4000; TH4000; Hypoxin; Tarloxotinib bromide; CAS#1636180-98-7.;(E)-4-((4-((3-bromo-4-chlorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)amino)-N,N-dimethyl-N-((1-methyl-4-nitro-1H-imidazol-5-yl)methyl)-4-oxobut-2-en-1-
• Target: Protein Tyrosine Kinase/RTK
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: [(E)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium;bromide
• InChI: InChI=1S/C24H23BrClN9O3.BrH/c1-33-14-30-24(34(37)38)20(33)12-35(2,3)8-4-5-22(36)32-21-10-16-19(11-27-21)28-13-29-23(16)31-15-6-7-18(26)17(25)9-15;/h4-7,9-11,13-14H,8,12H2,1-3H3,(H-,27,28,29,31,32,36);1H/b5-4+
• InChIKey: WAKIMVYUBWMMHJ-FXRZFVDSSA-N
• SMILES: CN1C=NC(=C1C[N+](C)(C)C/C=C/C(=O)NC2=NC=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)Cl)Br)[N+](=O)[O-].[Br-]

Tarloxotinib bromide（Cat No.:I009707）is an investigational small molecule inhibitor designed to target hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs), which are enzymes involved in the regulation of oxygen homeostasis in cells. By inhibiting these enzymes, tarloxotinib bromide aims to mimic the effects of oxygen, improving tumor oxygenation and potentially enhancing the effectiveness of cancer therapies, particularly in solid tumors. It has shown promise in preclinical studies for treating cancers that exhibit hypoxic microenvironments, such as non-small cell lung cancer. Clinical trials are underway to assess its safety, efficacy, and therapeutic potential.