Tarloxotinib bromide

• CAT Number: I009707
• CAS Number: 1636180-98-7
• Molecular Formula: C24H24Br2ClN9O3
• Molecular Weight: 681.774
• Purity: ≥95%
• Synonyms: PR-610; PR 610; PR610; TH-4000; TH 4000; TH4000; Hypoxin; Tarloxotinib bromide; CAS#1636180-98-7.;(E)-4-((4-((3-bromo-4-chlorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)amino)-N,N-dimethyl-N-((1-methyl-4-nitro-1H-imidazol-5-yl)methyl)-4-oxobut-2-en-1-
• Target: EGFR inhibitor
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: [(E)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium;bromide
• InChI: InChI=1S/C24H23BrClN9O3.BrH/c1-33-14-30-24(34(37)38)20(33)12-35(2,3)8-4-5-22(36)32-21-10-16-19(11-27-21)28-13-29-23(16)31-15-6-7-18(26)17(25)9-15;/h4-7,9-11,13-14H,8,12H2,1-3H3,(H-,27,28,29,31,32,36);1H/b5-4+
• InChIKey: WAKIMVYUBWMMHJ-FXRZFVDSSA-N
• SMILES: CN1C=NC(=C1C[N+](C)(C)CC=CC(=O)NC2=NC=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)Cl)Br)[N+](=O)[O-].[Br-]

Tarloxotinib bromide is a prodrug of a potent epidermal growth factor receptor (EGFR) inhibitor, designed to be activated under hypoxic conditions typical of solid tumors. This selective activation allows tarloxotinib to target tumor cells more effectively while minimizing damage to healthy tissues. It has shown promise in treating cancers with EGFR or HER2 mutations, including non-small cell lung cancer (NSCLC) and head and neck cancers. Research focuses on its potential to enhance the efficacy of cancer treatment while reducing side effects.