TAS-103 dihydrochloride

• CAT Number: I002278
• CAS Number: 174634-09-4
• Molecular Formula: C20H21Cl2N3O2
• Molecular Weight: 406.31
• Purity: ≥95%
• Target: Topoisomerase
• Solubility: H2O: ≤ 15.3 mg/mL
• Storage: Store at -20°C

TAS-103 dihydrochloride(CAT: I002278), also known as tosufloxacin tosilate, is a synthetic quinolone antibiotic. It is a dual inhibitor of topoisomerase I and II, enzymes involved in DNA replication and repair. TAS-103 has demonstrated potent antimicrobial activity against a broad range of bacteria, including both Gram-positive and Gram-negative strains. In addition to its antibacterial properties, TAS-103 has shown anticancer activity by inhibiting DNA topoisomerases, leading to DNA damage and cell death. It has been investigated as a potential treatment for various types of cancers, including lung, breast, and ovarian cancers.

Reference

[1]. Parajuli P, et al. Therapeutic efficacy of a new topoisomerase I and II inhibitor TAS-103, against both P-glycoprotein-expressing and -nonexpressing drug-resistant human small-cell lung cancer. Oncol Res. 1999;11(5):219-24.
[2]. Yoshida M, et al. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol Pharmacol. 2008 Mar;73(3):987-94.
[3]. Okamoto R, et al. Unique action determinants of double acting topoisomerase inhibitor, TAS-103. Int J Oncol. 2001 Nov;19(5):921-7.
[4]. Ewesuedo RB, et al. Phase I clinical and pharmacogenetic study of weekly TAS-103 in patients with advanced cancer. J Clin Oncol. 2001 Apr 1;19(7):2084-90.