TAS-109

• CAT Number: I009710
• CAS Number: 135598-68-4
• Molecular Formula: C10H12N4O4
• Molecular Weight: 252.23
• Purity: ≥95%
• Synonyms: TAS109; TAS109; TAS 109; DFP-10917; DFP 10917; DFP10917. CNDAC.;(2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile
• Target: Metabolic Enzyme/Protease
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile
• InChI: InChI=1S/C10H12N4O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-2,5-6,8-9,15-16H,4H2,(H2,12,13,17)/t5-,6+,8-,9+/m0/s1
• InChIKey: DCYBPMFXJCWXNB-JWIUVKOKSA-N
• SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)C#N

TAS-109(CAT: I009710) is a potent and selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases, used extensively in cancer research. By targeting FGFR signaling pathways, it plays a critical role in exploring mechanisms of tumor growth, angiogenesis, and resistance to therapies. TAS-109 is particularly valuable in studying FGFR-related malignancies, such as bladder, lung, and breast cancers. With its high specificity and stability, TAS-109 is suitable for in vitro and in vivo studies, providing researchers with a reliable tool to investigate FGFR-targeted therapies and develop innovative anticancer strategies.