TAS6417

For research use only. Not for therapeutic Use.

  • CAT Number: I019823
  • CAS Number: 1661854-97-2
  • Molecular Formula: C₂₃H₂₀N₆O
  • Molecular Weight: 396.44
  • Purity: ≥95%
Inquiry Now

TAS6417 (CAT: I019823) is a potent and selective oral inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. By inhibiting FGFR signaling, TAS6417 blocks the activation of downstream signaling pathways involved in cell proliferation, survival, and angiogenesis. TAS6417 has shown promising efficacy in preclinical studies against various FGFR-driven solid tumors, including lung cancer, gastric cancer, and bladder cancer. It has demonstrated antitumor activity in both in vitro and in vivo models and is being investigated as a potential targeted therapy for FGFR-altered cancers. TAS6417 holds promise as a novel treatment option for patients with FGFR-driven malignancies.


Catalog Number I019823
CAS Number 1661854-97-2
Molecular Formula C₂₃H₂₀N₆O
Purity ≥95%
Target Protein Tyrosine Kinase/RTK
IUPAC Name N-[(8S)-4-amino-6-methyl-5-quinolin-3-yl-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide
InChI 1S/C23H20N6O/c1-3-18(30)28-16-8-13(2)21-19(15-9-14-6-4-5-7-17(14)25-10-15)20-22(24)26-12-27-23(20)29(21)11-16/h3-10,12,16H,1,11H2,2H3,(H,28,30)(H2,24,26,27)/t16-/m0/s1
InChIKey MKCYPWYURWOKST-INIZCTEOSA-N
SMILES CC1=C[C@@H](CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C

Request a Quote