TASIN-1

• CAT Number: I011460
• CAS Number: 792927-06-1
• Molecular Formula: C18H28N2O3S
• Molecular Weight: 352.49
• Purity: ≥95%
• Synonyms: 1/’-((4-methoxyphenyl)sulfonyl)-4-methyl-1,4/’-bipiperidine
• Target: APC
• Solubility: Soluble in DMSO
• Storage: Store at -20C
• IUPAC Name: 1-[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine
• InChI: InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)16-9-13-20(14-10-16)24(21,22)18-5-3-17(23-2)4-6-18/h3-6,15-16H,7-14H2,1-2H3
• InChIKey: XCBHYDPDIJQQGM-UHFFFAOYSA-N
• SMILES: CC1CCN(CC1)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)OC

TASIN-1(CAT: I011460) is a selective small-molecule inhibitor targeting colorectal cancer cells with truncated adenomatous polyposis coli (APC) mutations. This compound induces cytotoxicity specifically in cancer cells harboring APC mutations while sparing normal cells, making it a valuable tool for precision oncology research. TASIN-1 disrupts key metabolic pathways, including cholesterol biosynthesis, leading to apoptosis in susceptible tumor cells. Its high specificity and efficacy make it suitable for in vitro and in vivo studies, supporting advancements in targeted therapies for colorectal cancer and other APC mutation-driven malignancies.