For research use only. Not for therapeutic Use.
TASIN-1 is a selective inhibitor of truncated APC gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 represents a potential therapeutic strategy for prevention and intervention in CRC with mutant APC[1].
| Catalog Number | R066910 |
| CAS Number | 792927-06-1 |
| Synonyms | 1-[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine |
| Molecular Formula | C18H28N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)16-9-13-20(14-10-16)24(21,22)18-5-3-17(23-2)4-6-18/h3-6,15-16H,7-14H2,1-2H3 |
| InChIKey | XCBHYDPDIJQQGM-UHFFFAOYSA-N |
| SMILES | CC1CCN(CC1)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)OC |
| Reference | [1]. Zhang L, et al. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Sci Transl Med. 2016 Oct 19;8(361):361ra140. |
