Tat-NR2B9c

• CAT Number: I003760
• CAS Number: 500992-11-0
• Molecular Formula: C105H188N42O30
• Molecular Weight: 2518.88
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: 10 mM in H2O
• Storage: 3 years -20C powder

Tat-NR2B9c (Cat.No:I003760) is a PSD95 inhibitor with EC50 of 7 nM, also inhibit p38. Tat-NR2B9c blocks NMDA-induced superoxide formation by prevents phosphorylation of the NOX2 p47phoxsubunit.

Reference

[1]. Teves LM et al. Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species. J Cereb Blood Flow Metab. 2016 Mar;36(3):555-61.

[2]. Chen Y et al. Tat-NR2B9c prevents excitotoxic neuronal superoxide production. J Cereb Blood Flow Metab. 2015 May;35(5):739-42.