Taurochenodeoxycholic Acid (sodium salt)

• CAT Number: R066732
• CAS Number: 6009-98-9
• Molecular Formula: C26H44NO6S • Na
• Molecular Weight: 521.7
• Purity: ≥95%
• Synonyms: NSC 681055;Taurochenodeoxycholate;TCDCA
• Target: Metabolic Enzyme/Protease
• Storage: -20°C
• InChI: InChI=1S/C26H45NO6S.Na/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29;/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/q;+1/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-;/m1./s1
• InChIKey: IYPNVUSIMGAJFC-HLEJRKHJSA-M
• SMILES: C[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]

Taurochenodeoxycholic acid (TCDCA) is a taurine-conjugated primary bile acid derived from chenodeoxycholic acid (CDCA; Item No. 10011286) in the liver and is one of the major bile acids in bile. Bile acids are major products of cholesterol metabolism and are essential for solubilization and transport of cholesterol and other dietary lipids. During an oral lipid tolerance test in human subjects, the levels of TCDCA rise approximately 5-fold in serum within two hours and begin to decrease within four hours. Serum levels of TCDCA, along with several other bile acids, are significantly increased in patients with liver cirrhosis and may serve as a marker of disease progression.

Reference

1.Hoffman, A.F. The continuing importance of bile acids in liver and intestinal disease. Arch. Intern. Med. 159(22), 2647-2658 (1999).