For research use only. Not for therapeutic Use.
Taurolithocholic acid (CAT: I037014) is a conjugated bile acid formed by the combination of lithocholic acid and taurine. It plays a role in lipid digestion and cholesterol metabolism by aiding the emulsification and absorption of dietary fats. TLCA is also known for its ability to act as a potent agonist of the G-protein-coupled bile acid receptor 1 (TGR5) and a modulator of the farnesoid X receptor (FXR), both of which are involved in regulating bile acid homeostasis, glucose metabolism, and energy balance. TLCA is widely used in metabolic disease and liver disease research to explore therapeutic strategies targeting bile acid signaling pathways.
| CAS Number | 516-90-5 |
| Synonyms | Taurolithocholic acid; Lithocholyltaurine; Lithocholic acid taurine conjugate; |
| Molecular Formula | C26H45NO5S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid |
| InChI | InChI=1S/C26H45NO5S/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32)/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1 |
| InChIKey | QBYUNVOYXHFVKC-GBURMNQMSA-N |
| SMILES | C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
