For research use only. Not for therapeutic Use.
Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].
Taurolithocholic acid (TLCA) at low concentrations (5 µM) tends to selectively increase the membrane-associated fraction of the e-isoform of PKC by 44.1% ± 40.2%[1].
TLCA (10 µM) selectively induces translocation of theε-isoform of PKC to the hepatocellular membranes, a key step for activation of mobile PKC isoforms[1].
Taurolithocholic acid (TLCA) exerts cholestatic effects via PI3K-dependent mechanisms in perfused rat Livers and rat hepatocyte couplets[2].
| Catalog Number | R010567 |
| CAS Number | 6042-32-6 |
| Synonyms | sodium;2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate |
| Molecular Formula | C26H44NNaO5S |
| Purity | ≥95% |
| InChI | InChI=1S/C26H45NO5S.Na/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3;/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32);/q;+1/p-1/t17-,18-,19-,20+,21-,22+,23+,25+,26-;/m1./s1 |
| InChIKey | YAERYJYXPRIDTO-HRHHVWJRSA-M |
| SMILES | CC(CCC(=O)NCCS(=O)(=O)[O-])C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C.[Na+] |
| Reference | [1]. U Beuers, et al. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology. 1999 Feb;29(2):477-82. [2]. Ulrich Beuers, et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem. 2003 May 16;278(20):17810-8. |
