Taxifolin

• CAT Number: I003687
• CAS Number: 480-18-2
• Molecular Formula: C15H12O7
• Molecular Weight: 304.25
• Purity: ≥95%
• Target: VEGFR2 kinase
• Solubility: DMSO：≥ 33 mg/mL
• Storage: -20°C
• IUPAC Name: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
• InChI: InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
• InChIKey: CXQWRCVTCMQVQX-LSDHHAIUSA-N
• SMILES: C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

Taxifolin（Cat No.:I003687）, also known as dihydroquercetin, is a flavanonol, which belongs to the class of flavonoids. This natural compound exhibits several beneficial properties, including antitumor and anti-diabetic effects. Taxifolin has been studied for its potential in inhibiting tumor growth and reducing cancer cell proliferation. Additionally, it has shown promise in managing diabetes by enhancing insulin sensitivity and reducing blood glucose levels. Due to its diverse pharmacological activities, taxifolin is of interest in the development of therapeutic interventions targeting cancer and diabetes.

Reference

[1]. Oi N, et al. Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K. Cancer Prev Res (Phila). 2012 Sep;5(9):1103-14.
[2]. Wang YH, et al. Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation. J Biomed Sci. 2006 Jan;13(1):127-41.
[3]. Vladimirov YA, et al. Dihydroquercetin (taxifolin) and other flavonoids as inhibitors of free radical formation at key stages of apoptosis. Biochemistry (Mosc). 2009 Mar;74(3):301-7.