For research use only. Not for therapeutic Use.
TB5 (Cat.No:I009722) is a MAO-B inhibitor. TB5 showed the inhibitory activity and selectivity toward hMAO-B, with Ki and SI values of 0.11±0.01 μm and 13.18, respectively. TB5 was found to be nontoxic at 5 and 25 μm, with 95.75 and 84.59 % viability among cells, respectively.
| Catalog Number | I009722 |
| CAS Number | 948841-07-4 |
| Synonyms | TB5; TB 5; TB-5.;(2E)-1-(5-bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one |
| Molecular Formula | C15H14BrNOS |
| Purity | ≥95% |
| Target | Monoamine Oxidase |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | (E)-1-(5-bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one |
| InChI | InChI=1S/C15H14BrNOS/c1-17(2)12-6-3-11(4-7-12)5-8-13(18)14-9-10-15(16)19-14/h3-10H,1-2H3/b8-5+ |
| InChIKey | PTLDLBSWTKNYCY-VMPITWQZSA-N |
| SMILES | CN(C)C1=CC=C(/C=C/C(C2=CC=C(Br)S2)=O)C=C1 |
| Reference | </br>1: Mathew B, Haridas A, Uçar G, Baysal I, Joy M, Mathew GE, Lakshmanan B, Jayaprakash V. Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors. ChemMedChem. 2016 Jun 6;11(11):1161-71. doi: 10.1002/cmdc.201600122. PubMed PMID: 27159243. |
