For research use only. Not for therapeutic Use.
TBB (Cat No.:I002263) is a selective and potent inhibitor of protein kinase CK2 (casein kinase 2). It inhibits CK2 activity by competing with ATP binding to the catalytic site of the kinase. CK2 is a serine/threonine kinase involved in various cellular processes, including cell proliferation, survival, and signal transduction. TBB has been widely used as a research tool to study CK2-related pathways and their role in disease processes. It has shown potential therapeutic applications in cancer treatment due to its ability to inhibit CK2-mediated cell proliferation and survival pathways. Additionally, TBB has been investigated for its anti-inflammatory and antiviral properties.
| Catalog Number | I002263 |
| CAS Number | 17374-26-4 |
| Synonyms | 4,5,6,7-tetrabromo-2H-benzotriazole |
| Molecular Formula | C6HBr4N3 |
| Purity | ≥95% |
| Target | CK2 |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 0.9 uM (Rat CK2); 1.6 μM (Human CK2) |
| IUPAC Name | 4,5,6,7-tetrabromo-2H-benzotriazole |
| InChI | InChI=1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13) |
| InChIKey | OMZYUVOATZSGJY-UHFFFAOYSA-N |
| SMILES | C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br |
| Reference | </br>1:Diagnosis of resistance alleles in codon 167 of the beta-tubulin (Cya-tbb-1) gene from third-stage larvae of horse cyathostomins. Ishii JB, Arenal A, Felix A, Yoshitani U, Beech R, Molento MB.Res Vet Sci. 2017 Jan 25;115:92-95. doi: 10.1016/j.rvsc.2017.01.019. [Epub ahead of print] PMID: 28199900 </br>2:Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP). Knudsen GA, Hughes MF, Sanders JM, Hall SM, Birnbaum LS.Toxicol Appl Pharmacol. 2016 Nov 15;311:117-127. doi: 10.1016/j.taap.2016.10.005. Epub 2016 Oct 11. PMID: 27732871 </br>3:Comparison of in vitro hormone activities of novel flame retardants TBB, TBPH and their metabolites TBBA and TBMEPH using reporter gene assays. Klopčič I, Skledar DG, Mašič LP, Dolenc MS.Chemosphere. 2016 Oct;160:244-51. doi: 10.1016/j.chemosphere.2016.06.091. Epub 2016 Jul 6. PMID: 27380226 </br>4:Effects of 4-META/MMA-TBB Resin at Different Curing Stages on Osteoblasts and Gingival Epithelial Cells. Morotomi T, Hirata-Tsuchiya S, Washio A, Kitamura C.J Adhes Dent. 2016;18(2):111-8. doi: 10.3290/j.jad.a35839. PMID: 27022642 </br>5:Development of an analytical method to quantify PBDEs, OH-BDEs, HBCDs, 2,4,6-TBP, EH-TBB, and BEH-TEBP in human serum. Butt CM, Miranda ML, Stapleton HM.Anal Bioanal Chem. 2016 Apr;408(10):2449-59. doi: 10.1007/s00216-016-9340-3. Epub 2016 Feb 10. PMID: 26864867 Free PMC Article</br>6:In vitro evaluation of adhesive characteristics of 4-META/MMA-TBB resin with organic filler. Saeki K, Chin AF, Nonomura GT, Hilton JF, Chien YC, Marshall SJ, Marshall GW.Dent Mater. 2015 Dec;31(12):1567-78. doi: 10.1016/j.dental.2015.10.004. Epub 2015 Nov 14. PMID: 26590030 </br>7:Inhibition of enamel demineralization and bond-strength properties of bioactive glass containing 4-META/MMA-TBB-based resin adhesive. Kohda N, Iijima M, Kawaguchi K, Toshima H, Muguruma T, Endo K, Mizoguchi I.Eur J Oral Sci. 2015 Jun;123(3):202-7. doi: 10.1111/eos.12187. Epub 2015 Apr 22. PMID: 25903115 </br>8:Biocompatibility of 4-META/MMA-TBB resin used as a dental luting agent. Nakagawa K, Saita M, Ikeda T, Hirota M, Park W, Lee MC, Ogawa T.J Prosthet Dent. 2015 Jul;114(1):114-21. doi: 10.1016/j.prosdent.2014.10.016. Epub 2015 Apr 14. PMID: 25882972 </br>9:Effect of a self-etching primer and phosphoric acid etching on the bond strength of 4-META/MMA-TBB resin to human enamel. Nogawa H, Koizumi H, Saiki O, Hiraba H, Nakamura M, Matsumura H.Dent Mater J. 2015;34(2):219-26. doi: 10.4012/dmj.2014-227. Epub 2015 Feb 24. PMID: 25740168 Free Article</br>10:A comparative study of the effects of 4-META/MMA-TBB resin and cyanoacrylate on wound healing of skin defects. Kidokoro R, Nakajima K, Kobayashi F, Takeda Y, Matsuzaka K, Katakura A, Inoue T.J Biomed Mater Res B Appl Biomater. 2016 Jan;104(1):197-203. doi: 10.1002/jbm.b.33375. Epub 2015 Feb 26. PMID: 25715705 |
