TBDPS-CHC

• CAT Number: I037026
• Molecular Formula: C26H25NO3Si
• Molecular Weight: 427.58
• Purity: 98%
• Synonyms: TBDPS-CHC
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (E)-3-(4-((tert-butyldiphenylsilyl)oxy)phenyl)-2-cyanoacrylic acid
• InChI: InChI=1S/C26H25NO3Si/c1-26(2,3)31(23-10-6-4-7-11-23,24-12-8-5-9-13-24)30-22-16-14-20(15-17-22)18-21(19-27)25(28)29/h4-18H,1-3H3,(H,28,29)/b21-18+
• InChIKey: ISJVSHIKNUAOEB-DYTRJAOYSA-N
• SMILES: O=C(O)/C(C#N)=C/C1=CC=C(O[Si](C2=CC=CC=C2)(C(C)(C)C)C3=CC=CC=C3)C=C1

TBDPS-CHC(CAT: I037026) is a novel and potent inhibitor of monocarboxylate transporter 1 (MCT1), a key regulator of lactate transport in cancer metabolism. By targeting MCT1, TBDPS-CHC disrupts lactate shuttling, impairing the metabolic flexibility of tumor cells and leading to metabolic stress and growth inhibition. It demonstrates promising single-agent anticancer efficacy, making it a valuable tool in oncology research. Researchers utilize TBDPS-CHC to explore the role of MCT1 in cancer cell survival, tumor microenvironment adaptation, and resistance to conventional therapies, as well as to develop targeted metabolic therapies for malignancies reliant on MCT1 activity.